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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could bring about an increase in methadone plasma concentrations, which could lead to perhaps fatal respiratory melancholy. On top of that, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may result in an in